Target-based discovery of a broad spectrum flukicide
D. J. Sprague, S.-K. Park, S. Gramberg…·J. Marchant
The paper identifies a new flukicide, BZQ, effective against both Fasciola and Schistosoma species by targeting a conserved TRPMPZQ ion channel.
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3 papers
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D. J. Sprague, S.-K. Park, S. Gramberg…·J. Marchant
The paper identifies a new flukicide, BZQ, effective against both Fasciola and Schistosoma species by targeting a conserved TRPMPZQ ion channel.
E. G. Chulkov, C. M. Rohr, J. Marchant
This study identifies a cation current activated by praziquantel in Schistosoma mansoni neuronal tissue, matching the properties of TRPMPZQ.
S.-K. Park, L. Friedrich, N. A. Yahya…·J. S. Marchant
This study identifies the mechanism by which praziquantel activates a specific ion channel in parasitic flatworms, explaining its efficacy against some species but not others.