BiophysicsbioRxiv
Autocrine inhibition of cell motility can drive epithelial branching morphogenesis in absence of growth
E. G. Rens, M. T. Zeegers, I. Rabbers…·R. M. H. Merks
The paper proposes a mechanism for epithelial branching morphogenesis without proliferation or mesenchymal interaction, showing autocrine TGFβ1 inhibits protrusions and drives branching through curvature-dependent inhibition.
DOI 10.1098/rstb.2019.0386