BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
Lecanemab Blocks the Effects of the Aβ/Fibrinogen Complex on Blood Clots and Synapse Toxicity in Organotypic Culture
P. K. Singh, E. N. Simoes-Pires, Z.-L. Chen…·E. H. Norris
This study shows lecanemab blocks Aβ/fibrinogen complex formation, reducing clot abnormalities and synaptotoxicity in AD models.
DOI 10.1073/pnas.2314450121