E. J. Cram

FLN-1/Filamin is required to anchor the actomyosin cytoskeleton and for global organization of sub-cellular organelles in a contractile tissue

This study shows that FLN-1/filamin anchors actomyosin fibers and maintains sub-cellular organelle organization in C. elegans spermatheca.

Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells.

This study shows that smooth muscle cells communicate via mechanical signaling to modulate calcium waves, independent of gap junctions, leading to altered agonist perception on stiff matrices.

Gα/GSA-1 works upstream of PKA/KIN-1 to regulate calcium signaling and contractility in the Caenorhabditis elegans spermatheca

This study identifies a signaling network in C. elegans spermatheca where Gα/GSA-1 and PKA/KIN-1 regulate calcium signaling and contractility through interactions with PLC-1 and PDE-6.

Atf-6 regulates lifespan through ER-mitochondrial calcium homeostasis

This study shows that Atf-6 extends lifespan in C. elegans by modulating ER-mitochondrial calcium homeostasis and signaling.

Redox signaling modulates Rho activity and tissue contractility in the C. elegans spermatheca

The paper shows redox signaling regulates RHO-1 activity and tissue contractility in C. elegans spermatheca via oxidation of a conserved cysteine residue.

The RhoGAP SPV-1 regulates calcium signaling to control the contractility of the C. elegans spermatheca during embryo transits.

Ancestral Roles of the Fam20C Family of Secreted Protein Kinases Revealed by Functional Analysis in C. elegans

This study identifies FAMK-1, the C. elegans ortholog of Fam20C, as essential for fertility, embryogenesis, and development through its role in maintaining cellular partitions and responding to mechanical strain.