Author

H. Parameswaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

R. R. Jamieson· 2 shared S. E. Stasiak· 2 shared S. R. Polio· 2 shared A. J. Welch· 1 shared A. L. Duncan· 1 shared A. Panda· 1 shared B. Smeets· 1 shared C. Brown· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBioengineering

R. R. Jamieson

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Author profile →

5 papers

Recent·Most cited

Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer

A. Panda, F. Giska, A. L. Duncan, A. J. Welch, C. Brown, R. McAllister, H. Parameswaran, J. N. D. Goder, J. Coleman, S. Ramakrishnan, F. Pincet, L. Guan, S. Krishnakumar, J. E. Rothman, K. Gupta

This paper develops a platform for analyzing integral membrane proteins and lipids in intact membranes using native mass spectrometry, showing how lipid binding and membrane composition affect protein function.

bioRxiv · Mar 12, 2023Biophysics

Stiffening of the Extracellular Matrix is a Sufficient Condition for AirwayHyperreactivity.

R. R. Jamieson, S. E. Stasiak, S. R. Polio, J. W. Ruberti, H. Parameswaran

This study shows that increasing airway extracellular matrix stiffness through collagen crosslinking leads to enhanced bronchoconstriction, suggesting matrix remodeling as a key driver of airway hyperreactivity in asthma.

bioRxiv · Jun 27, 2020Bioengineering

Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells.

S. E. Stasiak, R. R. Jamieson, J. Bouffard, E. J. Cram, H. Parameswaran

This study shows that smooth muscle cells communicate via mechanical signaling to modulate calcium waves, independent of gap junctions, leading to altered agonist perception on stiff matrices.

bioRxiv · Jun 25, 2020Biophysics

Intercellular adhesion stiffness moderates cell decoupling on stiff substrates

D. A. Vargas, T. Heck, B. Smeets, H. Ramon, H. Parameswaran, H. Van Oosterwyck

This paper develops a computational model of cell pairs on patterned substrates to study how intercellular adhesion stiffness influences cell decoupling on stiff substrates.

bioRxiv · Oct 13, 2019 · PreprintBioengineering

Extracellular matrix stiffness regulates force transmission pathways in multicellular ensembles of human airway smooth muscle cells.

S. R. Polio, S. Stasiak, R. Krishnan, H. Parameswaran

This study shows ECM stiffness regulates force transmission in human airway smooth muscle cell ensembles by switching between ECM and cell-cell force transmission pathways.

bioRxiv · Sep 28, 2018Bioengineering