Brain endothelial antigen presentation detains CD8+ T cells at the blood-brain barrier leading to its breakdown
S. Aydin, J. Pareja, V. M. Schallenberg, A. Klopstein, T. Gruber, N. Page, E. Kaba, U. Deutsch, A. Johnson, M. Schenk, D. Merkler, B. Engelhardt
The paper shows that brain endothelial antigen presentation inhibits CD8+ T-cell movement and causes BBB breakdown in MS.
bioRxiv · Oct 12, 2021 · PreprintImmunology