Unrestrained ESCRT-III drives chromosome fragmentation and micronuclear catastrophe
M. Vietri, S. W. Schultz, A. Bellanger, C. M. Jones, C. Raiborg, E. Skarpen, C. R. J. Pedurupillay, E. Kip, R. Timmer, A. Jain, P. Collas, R. L. Knorr, S. N. Grellscheid, H. Kusumaatmaja, A. Brech, , C. Campsteijn
This study shows that unrestrained ESCRT-III activity at micronuclei causes chromosome fragmentation and DNA damage, while it facilitates repair in primary nuclei.
bioRxiv · Jan 10, 2019Cell Biology