Author

A. Brech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 7 Approach:experimental assay· 6 Approach:microscopy & imaging analysis· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:electronic health records· 2 Organism:human· 2 Assay:imaging· 2

Frequent Co-Authors

H. Stenmark· 6 shared C. Raiborg· 3 shared A. Jain· 2 shared C. Campsteijn· 2 shared E. M. Wenzel· 2 shared E. Skarpen· 2 shared S. W. Schultz· 2 shared A. Bellanger· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersCell Biology

H. Stenmark

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis

S. Pust, A. Brech, C. S. Wegner, H. Stenmark, K. Haglund

This study identifies vesicle-mediated transport of ALIX and ESCRT-III to the midbody during cytokinesis, showing microtubule-dependent motility and the role of kinesin-1 in this process.

bioRxiv · Nov 22, 2022Cell Biology

Lysosome repair by ER-mediated cholesterol transfer

M. Radulovic, E. M. Wenzel, S. Gilani, L. K. K. Holland, A. H. Lystad, S. Phuyal, V. M. Olkkonen, A. Brech, M. Jäättelä, K. Maeda, C. Raiborg, H. Stenmark

The paper identifies an ER-mediated cholesterol transfer mechanism for lysosome repair independent of ESCRTs, involving PI4K2A and OSBP.

bioRxiv · Sep 26, 2022 · PreprintCell Biology

Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway

M. Lerche, M. Mathieu, L. Malerod, N. M. Pedersen, H. Hamidi, M. Chastney, B. M. H. Bruininks, S. Kaptan, G. Jacquemet, I. Vattulainen, P. Roca-Cusachs, A. Brech, F. Perez, G. Boncompain, S. Miserey, J. Ivaska

This study shows that integrin transport through the biosynthetic pathway rapidly alters adhesion receptor availability, enabling localized cell spreading and focal adhesion growth.

bioRxiv · Jul 12, 2022Cell Biology

Host autophagy mediates organ wasting and nutrient mobilization for tumor growth

T. E. Rusten, R. Khezri, P. Holland, T. A. Schoborg, I. Abramovich, S. Takats, C. Dillard, A. Jain, F. OFarrell, S. Schultz, W. Hagopian, E. M. Quintana, R. Ng, N. S. Katheder, M. M. Rahman, , E. Gottlieb

The paper shows that host autophagy drives organ wasting and nutrient mobilization to support tumor growth in Drosophila.

bioRxiv · Dec 4, 2020Cell Biology

Protein Crowding Mediates Membrane Remodeling in Upstream ESCRT-induced Formation of Intraluminal Vesicles

S. Liese, E. M. Wenzel, I. Kjos, R. V. Rojas Molina, S. W. Schultz, A. Brech, H. Stenmark, C. Raiborg, A. Carlson

This study shows upstream ESCRTs mediate membrane deformation and ILV formation through crowding and altering bending rigidity, without requiring ATP.

Proceedings of the National Academy of Sciences · Nov 2, 2020Peer-reviewedBiophysics

JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes

K. W. Tan, V. Nähse, C. Campsteijn, A. Brech, K. O. Schink, H. Stenmark

This study identifies JIP4 and Phafin2 as components of a tubular recycling pathway from macropinosomes, showing JIP4 recruitment via Phafin2's PtdIns3P binding.

bioRxiv · Sep 29, 2020Cell Biology

Unrestrained ESCRT-III drives chromosome fragmentation and micronuclear catastrophe

M. Vietri, S. W. Schultz, A. Bellanger, C. M. Jones, C. Raiborg, E. Skarpen, C. R. J. Pedurupillay, E. Kip, R. Timmer, A. Jain, P. Collas, R. L. Knorr, S. N. Grellscheid, H. Kusumaatmaja, A. Brech, , C. Campsteijn

This study shows that unrestrained ESCRT-III activity at micronuclei causes chromosome fragmentation and DNA damage, while it facilitates repair in primary nuclei.

bioRxiv · Jan 10, 2019Cell Biology

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

bioRxiv · Jul 4, 2018Immunology