Active maintenance of CD8+ T cell naivety through regulation of global genome architecture
B. E. Russ, K. Tsyganov, S. Quon, B. Yu, J. Li, J. K. Lee, M. Olshansky, Z. He, P. F. Harrison, A. Barugahare, M. See, S. Nuessing, A. E. Morey, V. A. Udupa, T. J. Bennett, , S. J. Turner
This study shows that transcription factors maintain CD8+ T cell naivety by enforcing a distinct chromatin architecture that remodels upon activation.
bioRxiv · Feb 26, 2023 · PreprintImmunology