Author

M. Doukas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Pathology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 2 Assay:imaging· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

A. Sacchetti· 2 shared A. Antanaviciute· 1 shared A. Liu· 1 shared A. Simmons· 1 shared B. Groot Koerkamp· 1 shared B. van der Roest· 1 shared B. van der Steen· 1 shared C. J. H. M. Meeussen· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCancer Biology

A. Sacchetti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Micron-resolution fiber mapping in histology independent of sample preparation

M. Georgiadis, F. auf der Heiden, H. Abbasi, L. Ettema, J. Nirschl, H. Moein Taghavi, M. Wakatsuki, A. Liu, W. H. D. Ho, M. Carlson, M. Doukas, S. A. Koppes, S. Keereweer, R. A. Sobel, K. Setsompop, , M. Menzel

This paper introduces ComSLI, a method to map fiber networks in histology without sample preparation, showing its application across tissues and diseases.

Nature Communications · Nov 5, 2025Peer-reviewedPathology

The origin of intestinal cancer in the context of inflammation

M. P. Verhagen, R. Joosten, M. Schmitt, N. Valimaki, A. Sacchetti, K. Rajamaki, J. Choi, P. Procopio, S. Silva, B. van der Steen, T. P. P. van den Bosch, D. Seinstra, M. Doukas, L. H. Augenlicht, L. A. Aaltonen, R. Fodde

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease

J. D. Windster, L. E. Kuil, N. J. M. Kakiailatu, A. Antanaviciute, A. Sacchetti, K. C. MacKenzie, J. Peulen-Zink, T. W. Kan, E. Bindels, E. de Pater, M. Doukas, S. Yousefi, T. S. Barakat, C. J. H. M. Meeussen, P. C. E. J. Sloots, , M. Alves

This study identifies two enteric glia classes in health and disease, showing Schwann-like glia persist in HSCR and can be targeted to stimulate neurogenesis in a zebrafish model.

bioRxiv · Sep 26, 2023Pathology

PD1+ T-cells correlate with Nerve Fiber Density as a prognostic biomarker in patients with resected perihilar cholangiocarcinoma.

X. Tan, M. Rosin, S. Appinger, J. Bednarsch, D. Liu, G. Wiltberger, J. Garcia Vallejo, S. Jang, Z. Czigany, S. Boroojerdi, N. Gaisa, P. Boor, R. Buelow, J. de Vos-Geelen, L. Valkenburg-van Iersel, , L. Heij

The paper investigates the association between PD1+ T-cells and nerve fiber density (NFD) in resected perihilar cholangiocarcinoma (pCCA) patients, finding that high NFD correlates with improved overall survival.

bioRxiv · Jan 7, 2022 · PreprintCancer Biology

Mutational impact of chronic alcohol use on stem cells in cirrhotic liver

M. Jager, E. Kuijk, R. Lieshout, M. Locati, N. Besselink, B. van der Roest, R. Janssen, S. Boymans, J. de Jonge, J. IJzermans, M. Doukas, M. Verstegen, R. van Boxtel, L. van der Laan, E. Cuppen

This study investigates the mutational impact of chronic alcohol use on liver stem cells in cirrhotic livers and finds no alcohol-specific mutational signatures but identifies enriched oncogenic mutations in cancer genes.

bioRxiv · Jul 11, 2019 · PreprintCancer Biology