ISG15-modification of the Arp2/3 complex restricts pathogen spread
Y. Zhang, B. M. Ripley, W. Ouyang, M. Sturtz, E. Upton, E. Luhmann, M. Vessely, R. Coloma, N. Schwery, S. M. Anthony, A. Goeken, T. O. Moninger, J. T. Harty, A. J. Klingelhutz, E. Lundberg, , L. Radoshevich
This study shows ISG15 modifies the Arp2/3 complex to restrict pathogen spread by slowing actin filament formation and stabilizing structures, but pathogens like Listeria exploit dysregulated ISGylation to enhance spread.
bioRxiv · Dec 27, 2022 · PreprintCell Biology