PhysiologybioRxivPreprint
LRH-1/NR5A2 regulates the PTGS2-PGE2-PTGER1 signalling axis contributing to islet survival and antidiabetic actions of the agonist BL001
E. Martin Vazquez, N. Cobo_Vuilleumier, R. Araujo Legido…·B. R. Gauthier
This study identifies BL001's mechanism of action through LRH-1/NR5A2 activation, showing it protects beta cells via the PTGS2-PGE2-PTGER1 signalling pathway.
DOI 10.1101/2021.11.02.466895