Author

V. Comaills

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

B. R. Gauthier· 2 shared E. Martin Vazquez· 2 shared F. J. Bermudez-Silva· 2 shared F. Martin· 2 shared P. I. Lorenzo· 2 shared S. Y. Romero-Zerbo· 2 shared A. Campo-Caro· 1 shared A. Crespo· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPhysiology

B. R. Gauthier

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

LRH-1/NR5A2 regulates the PTGS2-PGE2-PTGER1 signalling axis contributing to islet survival and antidiabetic actions of the agonist BL001

E. Martin Vazquez, N. Cobo_Vuilleumier, R. Araujo Legido, E. Nola, L. Lopez Bermudo, A. Crespo, S. Y. Romero-Zerbo, M. Garcia-Fernandez, A. Martin Montalvo, A. Rojas, V. Comaills, F. J. Bermudez-Silva, M. Gannon, F. Martin, P. I. Lorenzo, B. R. Gauthier

This study identifies BL001's mechanism of action through LRH-1/NR5A2 activation, showing it protects beta cells via the PTGS2-PGE2-PTGER1 signalling pathway.

bioRxiv · Nov 2, 2021 · PreprintPhysiology

The Metabesity Factor HMG20A Potentiates Astrocyte Survival and Reactivity Preserving Neuronal Integrity

P. I. Lorenzo, E. Fuente-Martin, J. M. Mellado-Gil, J. A. Guerrero Martinez, N. Cobo-Vuilleumier, V. Comaills, E. Martin Vazquez, S. Y. Romero-Zerbo, J. Munoz Franco, J. A. Perez-Caballo, S. Rivero-Canalejo, A. Campo-Caro, C. C. Lachaud, M. Aguilar Diosdado, E. Garcia Fuentes, , B. R. Gauthier

This paper shows HMG20A promotes astrocyte survival and reactivity in the adult brain, preserving neuronal integrity under metabolic stress.

bioRxiv · Feb 15, 2021 · PreprintCell Biology

Single cell proteomics of tumor compartments identifies differential kinase activities defining sensitivity to mTOR-PI3-kinase inhibition

N. M. Karabacak, Y. Zheng, T. D. Dubash, R. Burr, D. S. Micalizzi, B. S. Wittner, D. F. Wiley, V. Comaills, E. Emmons, K. Niederhoffer, U. Ho, L. Nieman, W. Haas, S. L. Stott, D. T. Ting, , S. Maheswaran

The paper uses single cell proteomics to identify kinase activity differences in tumor compartments, showing how they affect sensitivity to mTOR-PI3K inhibition.

bioRxiv · Jan 6, 2021 · PreprintCancer Biology