BiophysicsbioRxiv
How a highly acidic SH3 domain folds in the absence of its charged peptide target
V. Jaramillo- Martinez, M. J. Dominguez, G. M. Bell…·E. J. Stollar
This study investigates how a highly acidic yeast SH3 domain folds despite electrostatic repulsion, showing that salt stabilizes it and hydrophobic collapse offsets repulsion during folding.
DOI 10.1002/pro.4635