Localization of infection in neonatal rhesus macaques after oral viral challenge
T. J. Hope, R. A. Taylor, M. D. McRaven, A. M. Carias, M. R. Anderson, E. Matias, M. Arainga, E. J. Allen, K. A. Rogers, S. Gupta, V. Kulkarni, S. Lakhashe, R. Lorenzo-Redondo, Y. Thomas, A. Strickland, , R. M. Ruprecht
This study uses PET and fluorescent microscopy to track HIV distribution in neonatal rhesus macaques after oral challenge, showing virions localize to the rectal mucosa by four hours and the intestine contains the most infected cells at 96 hours.
PLOS Pathogens · Nov 18, 2021Peer-reviewedCell Biology