J. Su

The molecular basis of pine wilt disease resistance in Pinus massoniana

This study identifies three molecular resistance strategies in Pinus massoniana cultivars against pine wood nematodes using transcriptome and metabolome profiling.

Novel transcriptional activator TAC3 regulates age-dependent floral transition in Chinese fir

This study identifies TAC3 and its homologues as transcriptional co-activators that regulate age-dependent floral transition by modulating miR156 expression in Arabidopsis and Chinese fir.

Exposure assessment suggests some cytotoxic Bacillus cereus group genotypes can grow over 3 logs in HTST milk throughout the shelf life at temperature abuse conditions

This study develops an exposure assessment model to predict B. cereus group growth in HTST milk under temperature abuse conditions, showing some genotypes can reach 105 CFU/mL by day 35 of storage.

Phosphorylated transcription factor PuHB40 is involved in ROS-dependent anthocyanin biosynthesis in pear exposed to high-light stress

This study identifies PuHB40 as a phosphorylation-regulated transcription factor that mediates ROS-dependent anthocyanin biosynthesis in pear under high-light stress.

Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators

This paper demonstrates a label-free, real-time biosensing platform using frequency-locked optical microtoroids to detect membrane binding events at zeptomolar concentrations.

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis

This study uses single-cell spatial transcriptomics and optimal transport analysis to reveal therapy-induced changes in pancreatic cancer microenvironment interactions.

The novel nematicide chiricanine A suppresses Bursaphelenchus xylophilus pathogenicity in Pinus massoniana by inhibiting Aspergillus and its secondary metabolite, sterigmatocystin

The carbapenem inoculum effect provides insight into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales

This study shows that carbapenemase-producing CRE exhibit an inoculum effect, which can mislead susceptibility testing and highlights the need for improved detection methods.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

Comprehensive Multi-omics Analysis Reveals the Core Role of Glycerophospholipid Metabolism in Rheumatoid Arthritis Development

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C

This study shows MUC13 regulates tight junction proteins and intestinal barrier integrity through Protein Kinase C, with deletion of MUC13 increasing TJ protein levels and altering barrier function.

Disrupting peroxisomes alters lipid metabolism in melanoma and uncovers a novel therapeutic vulnerability in combination with MAPK-targeted therapies

This paper identifies a metabolic vulnerability in melanoma cells by disrupting peroxisomes and shows that combining this with MAPK-targeted therapies enhances anti-tumor effects.

Optimised whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells

The paper optimizes CRISPR interference screens in human iPSCs using dCas9-KRAB-MeCP2, identifies ARID1A-dependent growth regulators, and finds proteasome-related genes as synthetic lethal targets.

Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowths

This study introduces GoT-Splice, a multi-omics method to analyze splicing aberrations in human hematopoietic cells, revealing cell-type specific effects of SF3B1 mutations in clonal outgrowths.

Additive and Dominant Loci Jointly Pyramiding the Grain Quality of Hybrid Rice

The paper develops a pipeline to analyze grain quality traits in hybrid rice by identifying additive and dominant genetic loci, improving prediction accuracy for hybrid performance.

Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritis

The paper uses single-cell RNA sequencing to identify novel cell subsets in subchondral bone of OA patients and elucidates their roles in disease progression.

SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

Mucins form a nanoscale material barrier against immune cell attack

This study investigates how glycocalyx thickness, influenced by mucin properties, affects NK cell-mediated cytotoxicity and suggests strategies to enhance cancer immunotherapy.

Hypoxia Dynamically Regulates DBC1 Ubiquitination and Stability by SIAH2 and OTUD5 in Breast Cancer Progression

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

Isolated Grauer's gorilla populations differ in diet and gut microbiome

The study examines diet and gut microbiome differences in three isolated Grauer's gorilla populations, finding population-specific profiles and co-variation between diet and microbiome.

An integrated approach to protein discovery and detection from complex biofluids

This paper develops a mass spectrometry method to detect microproteins in vaginal lavages and identifies cystatin A as a potential biomarker for early ovarian cancer detection.

The class I TCP transcription factor AtTCP8 is a modulator of phytohormone-responsive signaling networks

The study identifies AtTCP8 as a modulator of phytohormone-responsive signaling networks, showing its role in brassinosteroid signaling and defense responses in Arabidopsis thaliana.

Lin28a rejuvenates muscle stem cells via mitochondrial optimization

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

Comparative genomic and pan-genomic characteristion of Staphylococcus epidermidis from different sources unveils the molecular basis and potential biomarkers of pathogenic strains

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

Simultaneous in vivo Pharmacokinetics and Pharmacodynamics of TDF Intravaginal Ring during High-dose Vaginal SHIV Challenge in Pigtail Macaques

This study examines TFV distribution and protection efficacy of a TDF IVR in macaques during high-dose SIV challenge, finding uneven TFV distribution and incomplete protection.

Integrative molecular and clinical profiling of acral melanoma identifies LZTR1 as a key tumor promoter and therapeutic target

Airway bacterial and fungal microbiome in chronic obstructive pulmonary disease

This study characterizes the airway bacterial and fungal microbiome in COPD patients and healthy controls, finding altered microbial diversity and interactions associated with disease severity.

CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

A Mycobacterium tuberculosis effector protein attacks host innate immunity by acting as an unusual ubiquitinating enzyme

This paper shows that Mtb PknG acts as an unusual ubiquitinating enzyme by promoting ubiquitination of TRAF2 and TAK1 to suppress host innate immunity.

Co-expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19 Infection

The paper identifies a corneal mitochondrial susceptibility module linked to SARS-CoV-2 infection by analyzing co-expression and interaction networks of ACE2 and related genes.