Simultaneous in vivo Pharmacokinetics and Pharmacodynamics of TDF Intravaginal Ring during High-dose Vaginal SHIV Challenge in Pigtail Macaques
K. Klotnik Halavaty, A. Ott, D. Maric, J. Su, E. Matias, E. J. Allen, A. Martin, L. E. Pereira, F. Deyounks, J. Smith, P. F. Kiser, T. J. Hope
This study examines TFV distribution and protection efficacy of a TDF IVR in macaques during high-dose SIV challenge, finding uneven TFV distribution and incomplete protection.
bioRxiv · Jun 29, 2021 · PreprintPharmacology & Toxicology