Author

Y. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:imaging· 3 Organism:human· 2 Organism:non-human primate· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

F. J. Villinger· 5 shared T. J. Hope· 5 shared M. Arainga· 4 shared M. D. McRaven· 4 shared R. Lorenzo-Redondo· 4 shared A. M. Carias· 3 shared M. R. Anderson· 3 shared C. Cicala· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersImmunology

F. J. Villinger

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo

J. Kime, D. Bose, M. Arainga, M. R. Haque, C. M. Fennessey, R. A. Caddell, Y. Thomas, D. E. Ferrell, S. Ali, E. Grody, Y. Goyal, C. Cicala, J. Arthos, B. F. Keele, M. Vaccari, , E. Marinelli

TGF-β blockade with galunisertib reverses SIV latency, reduces viral reservoirs, and enhances immune responses in ART-treated macaques without systemic inflammation.

bioRxiv · Sep 5, 2023Immunology

Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo

S. Samer, Y. Thomas, M. Arainga, C. Carter, L. M. Shirreff, M. S. Arif, J. M. Avitia, I. Frank, M. D. McRaven, C. T. Thuruthiyil, V. B. Heybeli, M. R. Anderson, B. Owen, A. Gaisin, D. Bose, , E. Marinelli

This study shows that blocking TGF-β signaling increases HIV-1 and SIV reactivation and boosts immune responses in infected individuals on ART.

bioRxiv · May 13, 2022Immunology

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques

P. J. Madden, Y. Thomas, R. V. Blair, S. Samer, M. Doyle, C. C. Midkiff, L. A. Doyle-Meyers, M. E. Becker, M. S. Arif, M. D. McRaven, L. M. Simons, A. M. Carias, E. Martinelli, R. Lorenzo-Redondo, J. F. Hultquist, , T. J. Hope

This paper uses immunoPET to track SARS-CoV-2 infection in rhesus macaques, revealing infection of the male genital tract and differences in lung pathology between SARS-CoV-2 variants.

bioRxiv · Feb 25, 2022 · PreprintImmunology

Localization of infection in neonatal rhesus macaques after oral viral challenge

T. J. Hope, R. A. Taylor, M. D. McRaven, A. M. Carias, M. R. Anderson, E. Matias, M. Arainga, E. J. Allen, K. A. Rogers, S. Gupta, V. Kulkarni, S. Lakhashe, R. Lorenzo-Redondo, Y. Thomas, A. Strickland, , R. M. Ruprecht

This study uses PET and fluorescent microscopy to track HIV distribution in neonatal rhesus macaques after oral challenge, showing virions localize to the rectal mucosa by four hours and the intestine contains the most infected cells at 96 hours.

PLOS Pathogens · Nov 18, 2021Peer-reviewedCell Biology

PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure

R. A. Taylor, S. Xiao, A. M. Carias, M. D. McRaven, D. N. Thakkar, M. Arainga, E. J. Allen, K. A. Rogers, S. C. Kumarapperuma, S. Gong, A. J. Fought, M. R. Anderson, Y. Thomas, J. R. Schneider, B. Goins, , T. J. Hope

The paper uses PET/CT and fluorescent microscopy to show dIgA increases HIV virion distribution and penetration in colorectal tissue and lymph nodes after exposure.

bioRxiv · Dec 23, 2020Cell Biology