Author

E. Needham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Rainbow· 2 shared J. L. Jones· 2 shared K. Saeb-Parsy· 2 shared L. B. Jarvis· 2 shared O. Suchanek· 2 shared A. Prabhu· 1 shared C. Dominguez Conde· 1 shared C. Xu· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

D. Rainbow

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Hiding in Plain Sight: Thymic CD8+FOXP3+Tregs sequester CD25 and are enriched in human tissues

L. B. Jarvis, S. K. Howlett, D. Rainbow, V. Coppard, R. Ferreira, E. Needham, A. Prabhu, S. Alkwai, L. Ellis, Z. Georgieva, O. Suchanek, H. S. Mousa, K. T. Mahbubani, K. Saeb-Parsy, L. S. Wicker, J. L. Jones

The paper identifies CD8+FOXP3+ Tregs enriched in human tissues, expressing intracellular CD25 and tissue residency markers, and demonstrates their therapeutic potential and association with disease states.

bioRxiv · Dec 24, 2023 · PreprintImmunology

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

C. Dominguez Conde, T. Gomes, L. B. Jarvis, C. Xu, S. Howlett, D. Rainbow, O. Suchanek, H. King, L. Mamanova, K. Polanski, N. Huang, E. Fasouli, K. Mahbubani, M. Prete, E. Tuck, , S. A. Teichmann

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

bioRxiv · Apr 28, 2021Immunology