T. Gomes

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

Single-cell sequencing of developing human gut reveals transcriptional links to childhood Crohns disease

The paper maps the developing human gut at 6-10 weeks post-conception using single-cell sequencing and links fetal transcriptional patterns to childhood Crohn's disease.

Distinct microbial and immune niches of the human colon

The paper examines microbial and immune cell interactions in the human colon, identifying distinct immune niches and T cell profiles along the colon.

A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

The paper uses single-cell transcriptomics to identify novel cell states in healthy and asthmatic lung tissues, revealing changes in cell communication and immune responses.

The IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.

Single cell transcriptomics of regulatory T cells reveals trajectories of tissue adaptation

The paper uses single-cell RNA-seq to study Treg and Tmem cells in mouse tissues, revealing a lymphoid-to-tissue adaptation trajectory and conserved molecular signals across species.

Gene expression variability across cells and species shapes innate immunity

The paper examines how gene expression variability across cells and species influences innate immune responses, finding that rapidly diverging genes show high variability while regulatory genes are conserved.