K. Mahbubani

Immunogenicity of autologous and allogeneic human primary cholangiocyte organoids

The immune response to human primary cholangiocyte organoids is ameliorated by donor-recipient HLA matching.

A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche

The paper creates a spatial multi-omics lung atlas identifying novel cell types and a survival niche for IgA-secreting plasma cells in submucosal glands.

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

The mutational landscape of normal human endometrial epithelium

This study characterizes the mutational landscape of normal human endometrial epithelium, revealing age-related mutation burdens and driver mutations in cancer genes.