H. King

Experimentally induced drought and growing season stage modulate community-level functional traits in a temperate grassland

The paper examines how drought and growing season timing affect functional traits in a temperate grassland, finding significant trait changes in drought conditions post-cutting.

Territorial aggression in male bower-building cichlids Nyassachromis cf. microcephalus is disrupted by exposure to environmental concentrations of fluoxetine

This study shows that fluoxetine exposure reduces territorial aggression in male cichlid fish, suggesting environmental serotonin disruption affects behavior.

Flexible estimation of biodiversity with short-range multispectral imaging in a temperate grassland

This study uses multispectral imaging from drones to estimate biodiversity metrics in a grassland, finding that spectral radiance variation correlates with biodiversity indices.

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

This study identifies PHGDH as essential for germinal center formation and shows its inhibition reduces lymphoma progression and improves survival.

Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery Against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin

This study identifies the molecular interaction between the PlyCB CBD of the PlyC endolysin and the pRha backbone of Group A Streptococcus and Streptococcus mutans cell wall polysaccharides.

Engineering protein-specific proteases: targeting active RAS

This study designs engineered proteases that specifically degrade active RAS by cleaving a conserved sequence in switch 2, showing efficacy in vitro and in human cell culture.

Structure of human RNA Polymerase III

The paper determines the structure of human RNA Polymerase III using cryo-EM and maps mutations linked to neurodevelopmental disorders and viral hypersensitivity.

A high-content screen profiles cytotoxic microRNAs in pediatric and adult glioblastoma cells and identifies miR-1300 as a potent inducer of cytokinesis failure

This study identifies miR-1300 as a potent cytotoxic microRNA in glioblastoma cells, causing cytokinesis failure and apoptosis, with potential therapeutic applications.