Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation
K. Zhu, Y. Wang, H. Sarlus, K. Geng, E. Nutma, J. Sun, S.-Y. Kang, C. Bay, J. Han, H. Lund, S. Amor, J. Wang, X.-m. Zhang, C. Kutter, A. Ortlieb, , R. Harris
The paper identifies TOP1 inhibitors as therapeutic agents for neuroinflammation and develops a DNA origami nanosystem for targeted delivery to myeloid cells.
bioRxiv · Oct 4, 2021Immunology