Author

C. Kutter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 6 Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

K. Geng· 3 shared A. Achour· 1 shared A. C. Roman· 1 shared A. Krstic· 1 shared A. Ortlieb· 1 shared A. Tannapfel· 1 shared A. Wagner· 1 shared A. Wiegard· 1 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

K. Geng

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CRISPR-Cas9-mediated genome engineering exaggerates genomic deletion at 10q23.31 including the PTEN gene locus mimicking cancer profiles

K. Geng, L. G. Merino, R. G. Veiga, C. Sommerauer, J. Epperlein, E. K. Brinkman, C. Kutter

This study identifies an unintended large genomic deletion at 10q23.31 in CRISPR-Cas9-modified HAP1 cells, which mimics cancer profiles and affects gene expression and histone modifications.

bioRxiv · Apr 5, 2023Cancer Biology

Co-inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription

D. P. Cameron, J. Grosser, S. Ladigan, V. Kuzin, E. Iliopoulou, A. Wiegard, H. Benredjem, S. T. Liffers, S. Lueong, P. F. Cheung, D. Vangala, M. Pohl, R. Viebahn, C. Teschendorf, H. Wolters, , L. Baranello

The paper shows that combining TOP1 and BRD4 inhibitors selectively kills pancreatic cancer cells by inducing readthrough transcription, without harming normal cells.

bioRxiv · Feb 10, 2023Cancer Biology

Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation

K. Zhu, Y. Wang, H. Sarlus, K. Geng, E. Nutma, J. Sun, S.-Y. Kang, C. Bay, J. Han, H. Lund, S. Amor, J. Wang, X.-m. Zhang, C. Kutter, A. Ortlieb, , R. Harris

The paper identifies TOP1 inhibitors as therapeutic agents for neuroinflammation and develops a DNA origami nanosystem for targeted delivery to myeloid cells.

bioRxiv · Oct 4, 2021Immunology

Molecular programming in utero modulates hepatic lipid metabolism and adult metabolic risk in obese mother offspring in a sex-specific manner

C. Savva, L. A. Helguero, M. Gonzalez-Granillo, T. Melo, D. Couto, B. Angelin, M. R. Domingues, X. Li, C. Kutter, M. Korach-Andre

The paper examines sex-specific metabolic differences in offspring of obese mothers, showing females have better metabolic outcomes due to more efficient transcriptional and posttranscriptional reprogramming.

bioRxiv · May 26, 2021Physiology

ZFP207 controls pluripotency by multiple post-transcriptional mechanisms

S. Malla, D. Prasad Bhattarai, D. Melguizo-Sanchis, I. Atanasoai, P. Groza, A. C. Roman, D. Zhu, D.-F. Lee, C. Kutter, F. Aguilo

This study identifies ZFP207's role in maintaining mouse embryonic stem cell identity through post-transcriptional mechanisms, including alternative splicing and RNA-binding protein activity.

bioRxiv · Mar 2, 2021 · PreprintCell Biology

FOXO1 and FOXO3 cooperatively regulate innate lymphoid cell development

T. L. Thanh, J. Norskov, L. P. Perez, S. Kharazi, A. Krstic, S. Meinke, L. Schmied, N. Frengen, Y. Heshmati, M. Kierczak, T. Bouderlique, A. Wagner, C. Gustafsson, B. Chambers, A. Achour, , N. Kadri

This study identifies FOXO1 and FOXO3 as cooperative regulators of innate lymphoid cell development and maturation, affecting lineage specification and response to IL-15.

bioRxiv · Jan 13, 2021Cell Biology