Author

E. O'Donnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. Sahaf· 1 shared D. M. Marquez· 1 shared E. M. Gibbs· 1 shared E. Meyer· 1 shared E.-A. D. Amir· 1 shared F. J. Hartmann· 1 shared H. T. Maecker· 1 shared I. Reacher· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperImmunology

B. Sahaf

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Peripheral mutations underlie promiscuous transport of quaternary ammonium antiseptics by Small Multidrug Resistance transporters

O. E. Burata, E. O'Donnell, J. Hyun, R. M. Lucero, J. E. Thomas, E. M. Gibbs, I. Reacher, N. A. Carney, R. B. Stockbridge

The paper identifies peripheral mutations that enable promiscuous transport of quaternary ammonium antiseptics by SMR transporters, revealing that substrate preference changes through mutations outside the binding pocket.

bioRxiv · Feb 6, 2024 · PreprintBiochemistry

Genetic Screen in a Pre-Clinical Model of High-Grade Complex Karyotype Sarcoma Characterizes Drivers of Distinct Sarcoma Subtypes and Identifies New Therapeutic Vulnerabilities

M. A. Munoz, J. Freeland, E. O'Donnell, J. Langerman, J. Bergonio, J. Surarez-Navarro, M. Darrow, S. Thorpe, R. Randall, K. L. Carraway, O. Witte, T. Graeber, J. Carr-Ascher

This paper develops a pre-clinical model of high-grade complex karyotype sarcomas to identify subtype-specific drivers and therapeutic targets through genetic screening and transcriptomic analysis.

bioRxiv · Jun 13, 2022 · PreprintCancer Biology

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

F. J. Hartmann, J. Babdor, P. F. Gherardini, E.-A. D. Amir, K. Jones, B. Sahaf, D. M. Marquez, P. Krutzik, E. O'Donnell, N. Sigal, H. T. Maecker, E. Meyer, M. H. Spitzer, S. C. Bendall

The paper presents a mass cytometry workflow for standardized immune monitoring in immunotherapy trials, identifying immune cell signatures and validating its robustness across samples and centers.

bioRxiv · Dec 13, 2018Immunology