E. Meyer

Twist-Dependent Elastic Limits and Unwinding of Tightly Bent DNA

This study investigates the elastic limits of tightly bent DNA under torsional strain, finding that DNA can be bent to 3.0 nm without kinking when helical repeats are 11 bp/turn due to twist-bend coupling.

Disease diagnostics using machine learning of immune receptors

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

Genetic variation in heat tolerance of the coral Platygyra daedalea indicates the potential for adaptation to ocean warming

This study identifies genetic variation associated with heat tolerance in the coral Platygyra daedalea, showing high heritability and complex genomic architecture.

Hyaluronan Synthesis Inhibition Impairs Antigen Presentation and Delays Transplantation Rejection

This study shows that inhibiting hyaluronan synthesis with 4MU impairs antigen presentation and delays transplant rejection in mice and human T-cell reactions.

Universal trends of post-duplication evolution revealed by the genomes of 13 Paramecium species sharing an ancestral whole-genome duplication.

This study analyzes 13 Paramecium species with a shared ancestral whole-genome duplication to reveal trends in post-duplication gene retention and selective pressures.

Heritable variation in bleaching responses and its functional genomic basis in reef-building corals (Orbicella faveolata)

This study estimates high heritability of bleaching responses in corals and identifies genetic markers and gene expression differences associated with thermal tolerance.

Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

The paper presents a mass cytometry workflow for standardized immune monitoring in immunotherapy trials, identifying immune cell signatures and validating its robustness across samples and centers.

Genomic and transcriptomic signals of thermal tolerance in heat-tolerant corals (Platygyra daedalea) of the Arabian/Persian Gulf

The paper assesses thermal tolerance in Gulf corals, finding high heritability and genetic markers linked to heat tolerance, with transcriptional differences between tolerant and susceptible families.