Sex-specific differences in the function and differentiation of ABCsmark TLR7-driven immunopathogenesis
E. Ricker, M. Manni, D. Flores-Castro, D. Jenkins, S. Gupta, J. Rivera-Correa, W. Meng, A. M. Rosenfeld, T. Pannellini, M. Bachu, Y. Chinenov, P. K. Sculco, R. Jessberger, E. T. Luning Prak, A. B. Pernis
The paper shows sex-specific differences in ABCs expansion, ISG signature upregulation, and differentiation in TLR7-driven immunopathogenesis, with Tlr7 duplication in males exacerbating disease severity.
bioRxiv · Jan 20, 2021 · PreprintImmunology