Author

N. Meednu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. Pitzalis· 3 shared S. Raychaudhuri· 3 shared A. Filer· 2 shared D. A. Rao· 2 shared D. L. Boyle· 2 shared F. Zhang· 2 shared G. S. Firestein· 2 shared K. Wei· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

C. Pitzalis

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3 papers

Recent·Most cited

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium

G. S. Dunlap, A. Wagner, N. Meednu, F. Zhang, A. H. Jonsson, K. Wei, S. Sakaue, A. Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (A, V. P. Bykerk, L. T. Donlin, S. M. Goodman, G. S. Firestein, D. L. Boyle, V. M. Holers, , J. Anolik

This study uses single-cell antigen receptor profiling to identify clonal relationships and functional states of T and B cells in RA synovium.

bioRxiv · Mar 18, 2023 · PreprintImmunology

Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression

N. Meednu, J. Rangel-Moreno, F. Zhang, K. Escalera-Rivera, E. Corsiero, E. Prediletto, E. Dicarlo, S. Goodman, L. Donlin, S. Raychaudhuri, M. Bombardieri, C. Pitzalis, D. Orange, AMP (RA/SLE) netwrok, A. McDavid, J. H. Anolik

The paper identifies NR4A-expressing B cells in RA synovium that show activated transcriptomic profiles and somatic hypermutation, suggesting in situ differentiation and roles in ELS and immune responses.

bioRxiv · May 14, 2021 · PreprintImmunology

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

L. T. Donlin, D. A. Rao, K. Wei, K. Slowikowski, M. J. McGeachy, J. D. Turner, N. Meednu, F. Mizoguchi, M. Gutierrez-Arcelus, D. J. Lieb, J. Keegan, K. Muskat, J. Hillman, C. Rozo, E. Ricker, , M. B Brenner

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

bioRxiv · Mar 19, 2018Immunology