Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance
Y. D. Muller, L. M. R. Ferreira, E. Ronin, P. Ho, V. Nguyen, G. Faleo, Y. Zhou, K. Lee, K. K. Leung, N. Skartsis, A. M. Kaul, A. Mulder, F. H. J. Claas, J. A. Wells, J. A. Bluestone, Q. Tang
This paper develops an anti-HLA-A2 CAR for Tregs to induce transplant tolerance, showing they target HLA-A2-expressing grafts and suppress immune rejection.
bioRxiv · Aug 16, 2021Immunology