Author

J. A. Bluestone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Bioengineering· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:human· 5 Approach:experimental assay· 4 Approach:genetic perturbation / CRISPR· 3 Organism:mouse· 3 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. Marson· 3 shared E. Shifrut· 3 shared F. Van Gool· 3 shared D. Goodman· 2 shared D. N. Nguyen· 2 shared J. A. Wells· 2 shared J. Li· 2 shared L. M. R. Ferreira· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

A. Marson

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

D. VanDyke, M. Iglesias, J. Tomala, A. Young, J. Smith, J. A. Perry, E. Gebara, A. R. Cross, L. S. Cheung, A. G. Dykema, B. T. Orcutt-Jahns, T. Henclova, J. Golias, J. Balolong, L. M. Tomasovic, , J. B. Spangler

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

bioRxiv · May 29, 2022Bioengineering

Precision engineering of an anti-HLA-A2 chimeric antigen receptor in regulatory T cells for transplant immune tolerance

Y. D. Muller, L. M. R. Ferreira, E. Ronin, P. Ho, V. Nguyen, G. Faleo, Y. Zhou, K. Lee, K. K. Leung, N. Skartsis, A. M. Kaul, A. Mulder, F. H. J. Claas, J. A. Wells, J. A. Bluestone, Q. Tang

This paper develops an anti-HLA-A2 CAR for Tregs to induce transplant tolerance, showing they target HLA-A2-expressing grafts and suppress immune rejection.

bioRxiv · Aug 16, 2021Immunology

The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28

Y. Muller, D. Nguyen, L. M. R. Ferreira, P. Ho, C. Raffin, R. Beltran Valencia, Z. Congrave-Wilson, T. Roth, J. Eyquem, F. Van Gool, A. M. R. Marson, J. A. Wells, J. A. Bluestone, Q. Tang

This paper shows that CD28-TMD in CARs forms heterodimers with endogenous CD28, affecting T-cell responses and surface expression.

bioRxiv · Sep 18, 2020Bioengineering

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

Y. Su, D. Chen, C. Lausted, D. Yuan, J. Choi, C. Dai, V. Voillet, K. Scherler, P. Troisch, V. R. Duvvuri, P. Baloni, G. Qin, B. Smith, S. Kornilov, C. Rostomily, , the

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

bioRxiv · Jul 27, 2020 · PreprintImmunology

CRISPR Screen in Regulatory T Cells Reveals Ubiquitination Modulators of Foxp3

J. T. Cortez, E. Montauti, E. Shifrut, Y. Zhang, O. Shaked, Y. Xu, T. Roth, D. Simeonov, Y. Zhang, S. Chen, Z. Li, I. A. Vogel, G. Y. Prator, B. Zhang, Y. Lee, , D. Fang

This study uses a CRISPR screen in mouse Tregs to identify genes regulating Foxp3 expression, finding Usp22 and Atxn7l3 as stabilizers and Rnf20 as a destabilizer.

bioRxiv · Feb 26, 2020 · PreprintImmunology

Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model

D. R. Holohan, F. Van Gool, J. A. Bluestone

This study investigates the role of thymically-derived Foxp3+ regulatory T cells (tTregs) versus peripherally-derived (pTregs) in type 1 diabetes (T1D) using NOD mice, finding that pTregs are not the primary regulators of T1D.

bioRxiv · May 20, 2019Immunology

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

T. L. Roth, P. J. Li, J. Nies, R. Yu, M. L. T. Nguyen, Y. Lee, R. Apathy, A. Truong, J. Hiatt, D. Wu, D. N. Nguyen, D. Goodman, J. A. Bluestone, K. Roybal, E. Shifrut, A. Marson

This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.

bioRxiv · Apr 12, 2019 · PreprintImmunology

A Cas9 nanoparticle system with truncated Cas9 target sequences on DNA repair templates enhances genome targeting in diverse human immune cell types

D. N. Nguyen, T. L. Roth, J. Li, P. A. Chen, M. M. Mamedov, L. T. Vo, V. Tobin, R. Apathy, D. Goodman, E. Shifrut, J. A. Bluestone, J. M. Puck, F. C. Szoka, A. Marson

The paper improves non-viral CRISPR-Cas9 genome editing in immune cells by using truncated Cas9 target sequences and polymer-stabilized nanoparticles, enhancing efficiency and viability.

bioRxiv · Mar 28, 2019 · PreprintBioengineering