Spectrin is a mechanoresponsive protein shaping the architecture of intercellular invasion
R. Duan, J. H. Kim, K. Shilagardi, E. Schiffhauer, S. Son, D. Lee, S. Li, C. Thomas, T. Luo, D. A. Fletcher, D. N. Robinson, E. H. Chen
The paper shows spectrin dynamically accumulates at fusogenic synapses in response to shear deformation, forming a sieve-like network that promotes cell membrane fusion during intercellular invasion.
bioRxiv · Jun 23, 2017Cell Biology