Cancer BiologybioRxivPreprint
AADAT-Driven Metabolic Control of Malate and CoQ10 Shapes Immune Evasion in Triple-Negative Breast Cancer
Megha Chatterjee, Franklin Gu, Susmita Samanta…·Arun Sreekumar
This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.