J. A. West

This study identifies ATP13A3 as a polyamine transporter whose deficiency leads to endothelial dysfunction and pulmonary arterial hypertension.

This study investigates circadian regulation of protein turnover and proteome renewal, finding that synthesis and degradation rhythms consolidate proteome renewal while minimizing compositional changes.

This study shows that amitosis in Tetrahymena provides evolutionary benefits similar to sex, enabling long-term success of asexual lineages by reducing mutation load and accelerating adaptation.