CD28 costimulatory domain protects against tonic signaling-induced functional impairment in CAR-Tregs
B. Lamarthee, A. Marchal, S. Charbonnier, T. Blein, E. Martin, K. Vogt, M. Titeux, M. Delville, H. Vincon, E. Six, N. Pallet, D. Anglicheau, C. Legendre, J.-L. Taupin, B. Sawitzki, , J. Zuber
This study compares CD28 and 4-1BB costimulatory domains in CAR-Tregs, finding CD28 better preserves function and survival under tonic signaling.
bioRxiv · Nov 19, 2020 · PreprintImmunology