Author

E. Somerville

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Sanyal· 3 shared T. Kirchhausen· 3 shared A. Saminathan· 2 shared G. Di Caprio· 2 shared G. Scanavachi· 2 shared A. Fountain· 1 shared A. Geneid· 1 shared A. J. B. Kreutzberger· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCell Biology

A. Sanyal

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Author profile →

4 papers

Recent·Most cited

Constitutive Endolysosomal Perforation in Neurons allows Induction of alpha-Synuclein Aggregation by Internalized Pre-Formed Fibrils

A. Sanyal, G. Scanavachi, E. Somerville, A. Saminathan, A. Nair, A. Oikonomou, N. S. Hatzakis, T. Kirchhausen

The paper shows that neurons have constitutive endolysosomal perforations enabling internalized alpha-synuclein fibrils to induce aggregation, and inhibiting PIKfyve kinase reduces this effect.

bioRxiv · Dec 30, 2023 · PreprintCell Biology

Deep neural network automated segmentation of cellular structures in volume electron microscopy

B. Gallusser, G. Maltese, G. Di Caprio, T. J. Vadakkan, A. Sanyal, E. Somerville, M. Sahasrabudhe, J. O'Connor, M. Weigert, T. Kirchhausen

This paper introduces ASEM, a deep learning pipeline for automated segmentation of cellular structures in electron microscopy, demonstrating its effectiveness in identifying various organelles and membrane structures.

bioRxiv · Aug 2, 2022Cell Biology

SARS-CoV-2 requires acidic pH to infect cells

A. J. B. Kreutzberger, A. Sanyal, A. Saminathan, L.-M. Bloyet, S. Stumpf, Z. Liu, R. Ojha, M. T. Patjas, A. Geneid, G. Scanavachi, C. A. Doyle, E. Somerville, R. Bango Da Cunha Correira, G. Di Caprio, S. Toppila-Salmi, , T. Kirchhausen

This study shows SARS-CoV-2 requires acidic pH for membrane fusion and genome release, even after proteolytic cleavage by furin or TMPRSS2.

bioRxiv · Jun 9, 2022Microbiology

Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes

C. Lancaster, A. Fountain, R. Dayam, E. Somerville, J. Sheth, V. Jacobelli, A. Somerville, M. Terebiznik, R. J. Botelho

This study shows that phagosome resolution through clathrin-dependent fragmentation regenerates lysosomes and maintains macrophage degradative capacity after multiple rounds of phagocytosis.

bioRxiv · May 14, 2020Cell Biology