Author

C. A. Doyle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

A. J. B. Kreutzberger· 2 shared G. Balistreri· 2 shared O. Vapalahti· 2 shared R. Ojha· 2 shared T. Kirchhausen· 2 shared A. Geneid· 1 shared A. Makitie· 1 shared A. Saminathan· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMicrobiology

A. J. B. Kreutzberger

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Novel TRPM7 inhibitors with potent anti-inflammatory effects in vivo

G. W. Busey, M. C. Manjegowda, T. Huang, W. H. Iobst, S. S. Naphade, J. A. Kennedy, C. A. Doyle, P. V. Seegren, K. R. Lynch, B. N. Desai

This study identifies novel TRPM7 inhibitors with potent in vivo anti-inflammatory effects, showing efficacy in a mouse model of endotoxemia.

bioRxiv · May 22, 2023 · PreprintImmunology

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein

K. Yang, C. Wang, A. J. B. Kreutzberger, R. Ojha, S. Kuivanen, S. Couoh-Cardel, S. Muratcioglu, T. J. Eisen, K. I. White, R. G. Held, S. Subramanian, K. Marcus, R. A. Pfuetzner, L. Esquivies, C. A. Doyle, , A. T. Brunger

bioRxiv · Aug 11, 2022Microbiology

SARS-CoV-2 requires acidic pH to infect cells

A. J. B. Kreutzberger, A. Sanyal, A. Saminathan, L.-M. Bloyet, S. Stumpf, Z. Liu, R. Ojha, M. T. Patjas, A. Geneid, G. Scanavachi, C. A. Doyle, E. Somerville, R. Bango Da Cunha Correira, G. Di Caprio, S. Toppila-Salmi, , T. Kirchhausen

This study shows SARS-CoV-2 requires acidic pH for membrane fusion and genome release, even after proteolytic cleavage by furin or TMPRSS2.

bioRxiv · Jun 9, 2022Microbiology