Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors
A. C. Johnston, G. M. Alicea, C. C. Lee, P. V. Patel, E. A. Hanna, E. Vaz, A. Forjaz, Z. Wan, P. R. Nair, Y. Lim, T. Chen, W. Du, D. Kim, T. D. Nichakawade, V. W. Rebecca, , D. Wirtz
This paper develops velocity receptors (VRs) to enhance CAR T cell migration through solid tumors, improving tumor infiltration and survival.
bioRxiv · Dec 13, 2023 · PreprintImmunology