Cancer BiologybioRxiv
MYC is sufficient to generate mid-life high-grade serous ovarian and uterine serous carcinomas in a p53-R270H mouse model
A. Blackman, A. C. Rees, R. R. Bowers…·J. R. Delaney
This paper shows that combining MYC and p53-R270H mutations in a mouse model generates high-grade serous ovarian and uterine serous carcinomas with human-like genetic and transcriptomic features.
DOI 10.1158/2767-9764.crc-24-0144