E. Yirmiya

This study identifies CARD-like domains in bacterial defense systems that activate gasdermin-mediated cell death against phage infection.

This study reveals the structural basis of the Gabija anti-phage defense complex and identifies a viral immune evasion mechanism through phage-encoded Gad1.

This study identifies a conserved family of immune effectors that degrade ATP and dATP during viral infection, halting phage propagation and suggesting a conserved innate immune strategy across life.

The paper identifies Tad1 proteins as inhibitors of TIR-domain signaling in bacterial antiphage systems, revealing gcADPR as the immune signaling molecule and its sequestration by Tad1.

This study identifies bacterial gasdermin homologs that execute prokaryotic cell death via caspase-like protease activation, revealing an ancient mechanism of regulated cell death shared with animals.

This study identifies bacterial proteins that deplete specific deoxynucleotides to inhibit phage replication, mirroring the human SAMHD1 antiviral mechanism.