Author

J. Garb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1 Assay:structural biology· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

R. Sorek· 4 shared A. Leavitt· 3 shared A. Millman· 3 shared G. Amitai· 3 shared E. Yirmiya· 2 shared P. J. Kranzusch· 2 shared S. Melamed· 2 shared A. B. Hill· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMicrobiology

R. Sorek

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Author profile →

4 papers

Recent·Most cited

CARD-like domains mediate anti-phage defense in bacterial gasdermin systems

T. Wein, A. G. Johnson, A. Millman, K. Lange, E. Yirmiya, R. Hadary, J. Garb, F. Steinruecke, A. B. Hill, P. J. Kranzusch, R. Sorek

This study identifies CARD-like domains in bacterial defense systems that activate gasdermin-mediated cell death against phage infection.

bioRxiv · May 28, 2023 · PreprintMicrobiology

Discovery of phage determinants that confer sensitivity to bacterial immune systems

A. Stokar-Avihail, T. Fedorenko, J. Garb, A. Leavitt, A. Millman, G. Shulman, N. Wojtania, S. Melamed, G. Amitai, R. Sorek

The paper identifies phage determinants that confer sensitivity to bacterial immune systems by analyzing 192 phage mutants escaping 19 defense systems.

bioRxiv · Aug 27, 2022Microbiology

Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

A. Leavitt, E. Yirmiya, G. Amitai, A. Lu, J. Garb, B. R. Morehouse, S. J. Hobbs, P. J. Kranzusch, R. Sorek

The paper identifies Tad1 proteins as inhibitors of TIR-domain signaling in bacterial antiphage systems, revealing gcADPR as the immune signaling molecule and its sequestration by Tad1.

bioRxiv · May 3, 2022Microbiology

Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion

J. Garb, A. Lopatina, A. Bernheim, M. Zaremba, V. Siksnys, S. Melamed, A. Leavitt, A. Millman, G. Amitai, R. Sorek

The paper shows DSR proteins deplete NAD+ during phage infection, inhibiting propagation, and identifies SIR2 domains as effector NADases in bacterial immunity.

bioRxiv · Dec 14, 2021Microbiology