PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells.
J. L. Hope, D. C. Otero, E.-A. Bae, C. J. Stairiker, A. B. Palete, H. A. Faso, M. L. Henriquez, H. Seo, X. Lei, E. S. Wang, R. Tinoco, A. R. Campos, J. Yin, P. D. Adams, A. Rao, L. M. Bradley
This study shows PSGL-1 modulates TCF-1/TOX axis to repress metabolism and promote T cell exhaustion in CD8+ T cells, making it a therapeutic target for PD-1/PD-L1 resistant tumors.
bioRxiv · Jan 24, 2022 · PreprintImmunology