Author

L. M. Bradley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. B. Palete· 1 shared A. R. Campos· 1 shared A. Rao· 1 shared C. J. Stairiker· 1 shared D. C. Otero· 1 shared E. Ruppin· 1 shared E. S. Wang· 1 shared E.-A. Bae· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

A. B. Palete

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedApr 19, 2023

Control of alveolar macrophage differentiation by Siah1a/2 ubiquitin ligases limits carcinogen-induced lung adenocarcinoma

M. Scortegagna, Y. Du, L. M. Bradley…·Z. A. Ronai

This study shows that Siah1a/2 ubiquitin ligases regulate alveolar macrophage differentiation, and their loss promotes lung adenocarcinoma by increasing immature macrophages and pro-tumorigenic inflammation.

DOI 10.1158/0008-5472.can-23-0258

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintJan 24, 2022

PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells.

J. L. Hope, D. C. Otero, E.-A. Bae…·L. M. Bradley

This study shows PSGL-1 modulates TCF-1/TOX axis to repress metabolism and promote T cell exhaustion in CD8+ T cells, making it a therapeutic target for PD-1/PD-L1 resistant tumors.

DOI 10.1101/2022.01.24.477602

humanexperimental assay

𝕏 PostBluesky