ImmunologybioRxivPreprint
PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells.
J. L. Hope, D. C. Otero, E.-A. Bae…·L. M. Bradley
This study shows PSGL-1 modulates TCF-1/TOX axis to repress metabolism and promote T cell exhaustion in CD8+ T cells, making it a therapeutic target for PD-1/PD-L1 resistant tumors.
DOI 10.1101/2022.01.24.477602