H. Seo

Butyrate as a growth factor of Clostridium acetobutylicum

This study shows that butyrate stimulates growth, health, and sporulation in Clostridium acetobutylicum and acts as a growth factor, potentially modulating microbial population dynamics.

Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma

The paper uses a novel computational workflow to analyze a spatiotemporally profiled GBM xenograft cohort, identifying 15 tumor cell programs related to invasion and their prognostic significance in GBM patients.

Chemical inhibition of stomatal differentiation by perturbation of the master-regulatory bHLH heterodimer via an ACT-Like domain

This study identifies Stomidazolone as a chemical inhibitor of the bHLH heterodimer MUTE-SCREAM, disrupting stomatal differentiation in plants.

Consolidated Bioprocessing of Lignocellulosic Biomass Poplar to Produce Short-Chain Esters by Clostridium thermocellum

Unrecognized Potent Activities of Colistin Against Clinically Important mcr+ Enterobacteriaceae Revealed in Synergy with Host Immunity

This study reveals that colistin has previously unrecognized bactericidal activity against mcr-1+ Gram-negative bacteria in physiologic conditions and synergizes with host immunity.

Balance-directed protein engineering of IsPETase enhances both PET hydrolysis activity and thermostability

This study engineers IsPETase to balance PET hydrolysis activity and thermostability, resulting in a variant that outperforms existing variants in depolymerization efficiency.

Existence of blood circulating immune-cell clusters (CICs) comprising antigen-presenting cells and B cells

The paper identifies circulating immune-cell clusters (CICs) composed of antigen-presenting cells and B cells in blood, showing increased frequency in COVID-19 patients.

PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells.

This study shows PSGL-1 modulates TCF-1/TOX axis to repress metabolism and promote T cell exhaustion in CD8+ T cells, making it a therapeutic target for PD-1/PD-L1 resistant tumors.

Probing Specificities of Alcohol Acyltransferases for Designer Ester Biosynthesis with a High-Throughput Microbial Screening Platform

This paper develops a high-throughput microbial screening platform to identify AATs for selective designer ester biosynthesis, demonstrating its effectiveness with specific AAT variants.

Broad-spectrum, patient-adaptable inhaled niclosamide-lysozyme particles are efficacious against coronaviruses in lethal murine infection models

This paper develops an inhaled niclosamide-lysozyme formulation effective against coronaviruses in mice, showing potent in vitro and in vivo activity against MERS-CoV and SARS-CoV-2.

Endogenous esterases of Clostridium thermocellum are identified and disrupted for enhanced isobutyl acetate production from cellulose

This study identifies and disrupts endogenous esterases in Clostridium thermocellum to enhance isobutyl acetate production from cellulose by reducing ester hydrolysis.