Aaron G. Baugh

The paper shows HDAC1 inhibition in MDSCs increases Malat1, decreases pSTAT3, induces apoptosis and cell cycle arrest, and reduces T cell suppression.

The paper investigates how myeloid-T cell interactions and B cell activation influence response to checkpoint inhibition in metastatic breast cancer using multi-omics and computational methods.

This paper introduces iterative logistic regression (iLR) to identify small sets of marker genes for subtle cell state changes, showing high accuracy in distinguishing cell subtypes and predicting therapeutic effects.

The paper identifies HTR2B on MDSCs as a target to enhance immune checkpoint inhibitors in breast-to-brain metastasis using clozapine and anti-PD-1 therapy.

The paper characterizes a novel syngeneic murine breast cancer model (NT2.5-LM) that exhibits rapid and widespread metastases, enabling study of metastatic progression and therapeutic responses.