Cancer BiologybioRxivPreprint
Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Immunity in Breast Cancer
Ian Eder, Masoumeh Baghaei, Sudeep K. Maurya…·Partha Sarathi Roy
This paper shows that reducing Profilin-1 in breast cancer cells triggers genomic instability and activates the cGAS-STING pathway, enhancing T cell-mediated anti-tumor immunity and leading to tumor regression.
DOI 10.64898/2026.06.05.730362