Author

Elizabeth G. Hunt

Every paper listing this name carries an ORCID.

Identified by ORCID

Elizabeth G. HuntiD2 papers · University of North Carolina at Chapel Hill

Biology Disciplines

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Andrew S. KennedyiD· 2 shared Brian P. RiesenbergiD· 2 shared Evelyn J. Gandy· 2 shared Jessica E. ThaxtoniD· 2 shared Katie E. HurstiD· 2 shared Peng GaoiD· 2 shared Alex M. AndrewsiD· 1 shared Coral del Mar Alicea Pauneto· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersImmunology

Andrew S. KennedyORCID

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2 papers

Recent·Most cited

ImmunologyCell MetabolismPeer-reviewedMar 14, 2024

Acetyl-CoA Carboxylase Obstructs CD8+ T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment

Elizabeth G. Hunt, Katie E. Hurst, Brian P. Riesenberg…·Jessica E. Thaxton

This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.

133 citationstop 1%

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ImmunologybioRxivPreprintNov 16, 2023

Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control

Brian P. Riesenberg, Evelyn J. Gandy, Andrew S. Kennedy…·Jessica E. Thaxton

This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.

DOI 10.1101/2023.11.16.567431

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