Andrew S. Kennedy

This study identifies folate receptor beta (FRβ) as a metabolic checkpoint on tumor-associated macrophages (TAMs) that promotes immunosuppression and tumor growth.

The paper uses in vivo single-cell gain-of-function screening to identify latent transcriptional programs that reprogram T cells into synthetic states with enhanced therapeutic potential.

This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.

This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.