An immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFα withdrawal
J. Y. Leong, P. Chen, J. G. Yeo, F. Ally, C. Chua, S. N. Hazirah, S. L. Poh, L. Pan, L. Lai, E. S. C. Lee, L. D. T. Bathi, Paediatric Rheumatology Collaborative Study, T. Arkachaisri, D. Lovell, S. Albani
The paper identifies an inflammatory CD4 T cell subset and transcriptomic signatures in JIA patients in remission that predict relapse after anti-TNFα withdrawal.
bioRxiv · May 31, 2019Immunology