C. Chua

Liver-specific Inflammatory Signatures Predict Clinically Significant Liver Damage.

The paper identifies liver-specific inflammatory signatures that precede clinically significant liver damage in CHB patients after NA withdrawal.

Pseudomonas aeruginosa isolates co-incubated with Acanthamoeba castellanii exhibit phenotypes similar to chronic cystic fibrosis isolates

This paper shows that Pseudomonas aeruginosa co-incubated with Acanthamoeba castellanii develops genetic and phenotypic traits similar to chronic cystic fibrosis isolates, suggesting similar selection pressures from different host environments.

An immunome perturbation is present in juvenile idiopathic arthritis patients who are in remission and will relapse upon anti-TNFα withdrawal

The paper identifies an inflammatory CD4 T cell subset and transcriptomic signatures in JIA patients in remission that predict relapse after anti-TNFα withdrawal.

Systemic sclerosis is a disease of a prematurely senescent, inflammatory and activated immunome

This study identifies altered immune architecture in systemic sclerosis, showing premature senescence of immune cells due to chronic stimulation.

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

This paper identifies HMGA2 as a regulator of DNA supercoiling and replication fork stability, showing its protective role against DNA damage from topoisomerase poisons and its potential as a therapeutic marker in cancer.